Caruthersville
- Country: United States
- State: Missouri
- Population: 5,801 (2016)
- Latitude: 36° 11.6' N (36.19312°)
- Longitude: 89° 39.3' W (-89.65564°)
- Elevation: 84 m/276 ft. above sea level
- Time zone: America/Chicago (UTC -06:00); DST observed (UTC -05:00)